David Blum Selected Research

GW406381X

9/2009	A randomized, controlled, dose-ranging study investigating single doses of GW406381, naproxen sodium, or placebo in patients with acute pain after third molar tooth extraction.
6/2009	A randomized, double-blind, placebo-controlled trial of a selective COX-2 inhibitor, GW406381, in patients with postherpetic neuralgia.
1/2008	Evaluation of GW406381 for treatment of osteoarthritis of the knee: two randomized, controlled studies.

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David Blum Research Topics

Disease

36	Alzheimer Disease (Alzheimer's Disease) 06/2022 - 07/2006
28	Seizures (Absence Seizure) 10/2022 - 10/2001
20	Tauopathies 01/2021 - 08/2010
20	Huntington Disease (Huntington's Disease) 06/2018 - 08/2002
18	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2022 - 06/2003
13	Neoplasms (Cancer) 11/2022 - 01/2010
11	Cognitive Dysfunction 01/2021 - 08/2010
10	Pain (Aches) 11/2021 - 03/2007
9	Parkinson Disease (Parkinson's Disease) 06/2022 - 06/2003
8	Epilepsy (Aura) 10/2022 - 10/2001
6	Memory Disorders (Memory Loss) 01/2022 - 06/2012
6	Body Weight (Weight, Body) 01/2021 - 01/2013
5	Inflammation (Inflammations) 06/2022 - 02/2005
5	Dementia (Dementias) 11/2021 - 08/2010
5	Dizziness (Lightheadedness) 01/2020 - 08/2006
4	Neuroinflammatory Diseases 11/2021 - 01/2018
4	Gliosis 01/2021 - 04/2007
4	Amyloid Plaque 11/2018 - 05/2012
3	Traumatic Brain Injuries (Traumatic Brain Injury) 06/2022 - 11/2021
3	Death (Near-Death Experience) 05/2022 - 01/2021
3	Delirium 01/2021 - 01/2020
3	Cachexia 01/2021 - 03/2010
3	Nervous System Diseases (Neurological Disorders) 01/2019 - 06/2003
3	Headache (Headaches) 11/2018 - 03/2007
2	Stroke (Strokes) 06/2022 - 06/2003
2	Myotonic Dystrophy (Dystrophia Myotonica) 01/2022 - 01/2019
2	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 12/2021 - 11/2019
2	Nausea 01/2020 - 01/2018
2	Sleepiness 01/2020 - 01/2016
2	Atrophy 01/2019 - 01/2007
2	Hyponatremia 01/2019 - 01/2018
2	Insulin Resistance 01/2019 - 01/2018
2	Hypothyroidism 01/2019 - 11/2014
2	Burkitt Lymphoma (Burkitt's Lymphoma) 01/2018 - 01/2015
2	Multiple Sclerosis 08/2012 - 10/2007
2	Hypothermia 04/2012 - 11/2011
2	Neuralgia (Stump Neuralgia) 07/2009 - 10/2007
2	Postherpetic Neuralgia 06/2009 - 10/2007
2	Osteoarthritis 06/2008 - 01/2008
1	Brain Neoplasms (Brain Tumor) 11/2022
1	Partial Epilepsies (Epilepsy, Partial) 10/2022
1	Malnutrition (Nutritional Deficiencies) 01/2022

Drug/Important Bio-Agent (IBA)

21	eslicarbazepine acetateIBA 01/2021 - 02/2015
16	Amyloid (Amyloid Fibrils)IBA 01/2022 - 06/2012
14	tau Proteins (tau Protein)IBA 01/2022 - 07/2010
13	Anticonvulsants (Antiepileptic Drugs)IBA 01/2020 - 08/2006
8	Peptides (Polypeptides)IBA 11/2021 - 01/2010
6	Biomarkers (Surrogate Marker)IBA 11/2021 - 03/2013
6	Caffeine (No Doz)FDA LinkGeneric 01/2019 - 10/2013
6	Lamotrigine (Lamictal)FDA LinkGeneric 11/2018 - 02/2005
6	3-nitropropionic acidIBA 12/2007 - 10/2002
5	Pharmaceutical PreparationsIBA 10/2022 - 06/2008
5	Proteins (Proteins, Gene)FDA Link 12/2021 - 01/2011
5	Adenosine (Adenocard)FDA LinkGeneric 01/2021 - 06/2003
5	Adenosine A2A Receptor (Adenosine A2A Receptors)IBA 11/2019 - 04/2007
4	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2015
4	Brain-Derived Neurotrophic Factor (BDNF)IBA 09/2015 - 05/2007
3	Apomorphine FDA Link 01/2021 - 01/2020
3	Amyloid beta-PeptidesIBA 11/2019 - 04/2014
3	Insulin (Novolin)FDA Link 01/2019 - 01/2018
3	Hormones (Hormone)IBA 01/2019 - 01/2018
3	Carbamazepine (Tegretol)FDA LinkGeneric 11/2018 - 08/2006
3	Purinergic P1 Receptors (Adenosine Receptor)IBA 06/2018 - 06/2003
3	N-Methylaspartate (NMDA)IBA 05/2013 - 06/2005
3	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 09/2009 - 06/2008
3	GW406381XIBA 09/2009 - 01/2008
3	Gabapentin (Neurontin)FDA LinkGeneric 07/2009 - 08/2006
3	Minocycline (Cyclops)FDA LinkGeneric 01/2007 - 12/2004
2	Neuroprotective AgentsIBA 06/2022 - 12/2007
2	Levetiracetam (Keppra)FDA LinkGeneric 01/2021 - 01/2018
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2021 - 01/2018
2	GhrelinIBA 01/2021 - 11/2011
2	Levodopa (L Dopa)FDA LinkGeneric 01/2020 - 05/2013
2	SodiumIBA 01/2019 - 01/2018
2	Protein Isoforms (Isoforms)IBA 01/2019 - 08/2010
2	Huntingtin ProteinIBA 06/2018 - 01/2008
2	EnzymesIBA 01/2018 - 04/2016
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2018 - 01/2017
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 11/2017 - 04/2016
2	Messenger RNA (mRNA)IBA 04/2016 - 01/2015
2	ChemokinesIBA 10/2015 - 01/2015
2	CytokinesIBA 01/2015 - 11/2014
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2013 - 06/2008
2	polyglutamineIBA 01/2011 - 01/2008
2	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 07/2009 - 10/2007
2	Nerve Growth Factors (Neurotrophins)IBA 01/2008 - 11/2007
2	Tetracycline (Achromycin)FDA LinkGeneric 01/2007 - 12/2004
1	N 30IBA 11/2022
1	Lacosamide FDA Link 10/2022
1	brivaracetamIBA 10/2022
1	ProteomeIBA 06/2022
1	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 01/2022
1	Doxycycline (Periostat)FDA LinkGeneric 01/2022
1	XenobioticsIBA 01/2022

Therapy/Procedure

14	Therapeutics 10/2022 - 06/2003
11	Palliative Care (Palliative Therapy) 11/2021 - 03/2010
4	Radiotherapy 11/2022 - 09/2021
2	Biological Therapy 12/2021 - 11/2021
2	Transjugular Intrahepatic Portasystemic Shunt 01/2021 - 11/2020
2	Institutionalization (Institutionalized Persons) 01/2021 - 01/2020